Brand name: Zurzuvae
Arnaud 25, CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Commons
What’s the Fuss?
Washington Post, 8-7-23:
What’s the Literature Say?
There are 3 articles about zuranolone for PPD, of which #3 is a re-analysis of the data in #1
#2 has not yet been released
There’s at least 1 article about it for plain depression
2 of the 3 postpartum articles feature several authors employed by the drug manufacturer
All 3 seem to be from the same research group
More patients responded or remitted with zuranolone than with placebo
NNT = 4.2 for response, 4.7 for remission
15-day Hamilton scores in study #1:
zuranolone: 10.6
placebo: 15.2
Treatment was for 14 days only; analysis continued to 45 days, and results persisted
Generally well-tolerated
Article #1
Article #3
But the web version appears to be freely available